Chemotherapy + Immunotherapy vs Immunotherapy Alone for Older (>70yo) Adults With Stage IIIB-IV Lung Cancer, The ACHIEVE Trial
This study is looking at the benefits of combining two cancer treatments—chemotherapy and a specific immunotherapy called pembrolizumab—for older people with advanced lung cancer (stages IIIB to IV).
Immunotherapy like pembrolizumab works by boosting your body's immune system to help it fight the cancer. It can also block cancer cells from growing and spreading.
Chemotherapy uses different drugs to target and kill cancer cells, or stop them from dividing and spreading. However, chemotherapy is usually not targeted and often leads to many unwanted side effects associated with cancer treatment.
The goal is to evaluate the value of combining chemotherapy with immunotherapy in controlling lung cancer and if it leads to longer overall survival.
NCT06096844
Chemotherapy + Pembrolizumab vs Pembrolizumab alone
All drugs are established and used widely. The goal is to find merit in adding the two in older adults.
- This study aims to find out if older adults with cancer live longer when treated with both chemotherapy and pembrolizumab, compared to just pembrolizumab alone.
- Age: You must be 70 years old or older.
- Type of Cancer: You have non-small cell lung cancer.
- Cancer Stage: Your cancer is at an advanced stage (IIIB, IIIC, or IV) and not suitable for combined chemo-radiation therapy. If you have had chemo-radiation before and the cancer came back, you can still join.
- Cancer Markers: Your cancer must not have certain genetic markers (EGFR mutation/ALK translocations).
- Health Status: Your overall health should allow only limited activity (ECOG Performance Status of 2).
- Family Planning: If you can father children, you must agree not to during the study and for 6 months afterward.
- Consent: You need to be able to understand and sign the consent form yourself, or have a legal representative who can consent for you if you are not able to make decisions yourself.
- Blood Tests: Results from recent blood tests must meet specific criteria (details about blood cell counts, liver and kidney function).
- Infections: If you have HIV or hepatitis, it must be well-controlled.
- Other Cancers: If you have had another type of cancer, it must not affect this study.
- Language: You must speak English or Spanish (for quality of life study part).
Who may not participate (Exclusion criteria)?
Idaho Locations
Boise, Idaho, United States, 83706
- Recruiting: Saint Alphonsus Cancer Care Center-Boise
- Contact: Site Public Contact, 734-712-3671, stephanie.couch@stjoeshealth.org
- Principal Investigator: John M. Schallenkamp
Caldwell, Idaho, United States, 83605
- Recruiting: Saint Alphonsus Cancer Care Center-Caldwell
- Contact: Site Public Contact, 734-712-3671, stephanie.couch@stjoeshealth.org
- Principal Investigator: John M. Schallenkamp
Coeur d'Alene, Idaho, United States, 83814
- Recruiting: Kootenai Health - Coeur d'Alene
- Contact: Site Public Contact, 406-969-6060, mccinfo@mtcancer.org
- Principal Investigator: John M. Schallenkamp
Nampa, Idaho, United States, 83687
- Recruiting: Saint Alphonsus Cancer Care Center-Nampa
- Contact: Site Public Contact, 406-969-6060, mccinfo@mtcancer.org
- Principal Investigator: John M. Schallenkamp
Post Falls, Idaho, United States, 83854
- Recruiting: Kootenai Clinic Cancer Services - Post Falls
- Contact: Site Public Contact, 406-969-6060, mccinfo@mtcancer.org
- Principal Investigator: John M. Schallenkamp
Sandpoint, Idaho, United States, 83864
- Recruiting: Kootenai Cancer Clinic
- Contact: Site Public Contact, 406-969-6060, mccinfo@mtcancer.org
- Principal Investigator: John M. Schallenkamp
Illinois Locations
Chicago, Illinois, United States, 60612
- Recruiting: University of Illinois
- Contact: Site Public Contact, 312-355-3046
- Principal Investigator: Frank Weinberg
Danville, Illinois, United States, 61832
- Recruiting: Carle at The Riverfront
- Contact: Site Public Contact, 800-446-5532, Research@Carle.com
- Principal Investigator: Tanmay Sahai
Decatur, Illinois, United States, 62526
- Recruiting: Cancer Care Specialists of Illinois - Decatur
- Contact: Site Public Contact, 217-876-4762, morganthaler.jodi@mhsil.com
- Principal Investigator: Bryan A. Faller
Decatur, Illinois, United States, 62526
- Recruiting: Decatur Memorial Hospital
- Contact: Site Public Contact, 217-876-4762, morganthaler.jodi@mhsil.com
- Principal Investigator: Bryan A. Faller
Effingham, Illinois, United States, 62401
- Recruiting: Carle Physician Group-Effingham
- Contact: Site Public Contact, 800-446-5532, Research@carle.com
- Principal Investigator: Tanmay Sahai
Effingham, Illinois, United States, 62401
- Recruiting: Crossroads Cancer Center
- Contact: Site Public Contact, 217-876-4762, morganthaler.jodi@mhsil.com
- Principal Investigator: Bryan A. Faller
Mattoon, Illinois, United States, 61938
- Recruiting: Carle Physician Group-Mattoon/Charleston
- Contact: Site Public Contact, 800-446-5532, Research@carle.com
- Principal Investigator: Tanmay Sahai
Springfield, Illinois, United States, 62702
- Recruiting: Southern Illinois University School of Medicine
- Contact: Site Public Contact, 217-545-7929
- Principal Investigator: Bryan A. Faller
Springfield, Illinois, United States, 62702
- Recruiting: Springfield Clinic
- Contact: Site Public Contact, 800-444-7541
- Principal Investigator: Bryan A. Faller
Springfield, Illinois, United States, 62781
- Recruiting: Memorial Medical Center
- Contact: Site Public Contact, 217-528-7541, pallante.beth@mhsil.com
- Principal Investigator: Bryan A. Faller
Urbana, Illinois, United States, 61801
- Recruiting: Carle Cancer Center
- Contact: Site Public Contact, 800-446-5532, Research@carle.com
- Principal Investigator: Tanmay Sahai
Iowa Locations
Ankeny, Iowa, United States, 50023
- Recruiting: Mission Cancer and Blood - Ankeny
- Contact: Site Public Contact, 515-282-2921
- Principal Investigator: Joshua Lukenbill
Cedar Rapids, Iowa, United States, 52403
- Recruiting: Mercy Hospital
- Contact: Site Public Contact, 319-365-4673
- Principal Investigator: Deborah W. Wilbur
Cedar Rapids, Iowa, United States, 52403
- Recruiting: Oncology Associates at Mercy Medical Center
- Contact: Site Public Contact, 319-363-2690
- Principal Investigator: Deborah W. Wilbur
Clive, Iowa, United States, 50325
- Recruiting: Medical Oncology and Hematology Associates-West Des Moines
- Contact: Site Public Contact, 515-241-3305
- Principal Investigator: Richard L. Deming
Clive, Iowa, United States, 50325
- Recruiting: Mercy Cancer Center-West Lakes
- Contact: Site Public Contact, 515-358-6613, cancerresearch@mercydesmoines.org
- Principal Investigator: Richard L. Deming
Des Moines, Iowa, United States, 50309
- Recruiting: Medical Oncology and Hematology Associates-Des Moines
- Contact: Site Public Contact, 515-241-3305
- Principal Investigator: Joshua Lukenbill
Des Moines, Iowa, United States, 50314
- Recruiting: Mercy Medical Center - Des Moines
- Contact: Site Public Contact, 515-358-6613, cancerresearch@mercydesmoines.org
- Principal Investigator: Richard L. Deming
Des Moines, Iowa, United States, 50314
- Recruiting: Mission Cancer and Blood - Laurel
- Contact: Site Public Contact, 515-241-3305
- Principal Investigator: Richard L. Deming
Maryland Locations
Baltimore, Maryland, United States, 21215
- Recruiting: Sinai Hospital of Baltimore
- Contact: Site Public Contact, 410-601-6120, pridgely@lifebridgehealth.org
- Principal Investigator: Vishal Jindal
Westminster, Maryland, United States, 21157
- Recruiting: William E Kahlert Regional Cancer Center/Sinai Hospital
- Contact: Site Public Contact, 410-871-6400
- Principal Investigator: Vishal Jindal
Michigan Locations
Brighton, Michigan, United States, 48114
- Recruiting: Trinity Health IHA Medical Group Hematology Oncology - Brighton
- Contact: Site Public Contact, 734-712-7251, MCRCwebsitecontactform@stjoeshealth.org
- Principal Investigator: Christopher M. Reynolds
Canton, Michigan, United States, 48188
- Recruiting: Trinity Health IHA Medical Group Hematology Oncology - Canton
- Contact: Site Public Contact, 734-712-7251, MCRCwebsitecontactform@stjoeshealth.org
- Principal Investigator: Christopher M. Reynolds
Chelsea, Michigan, United States, 48118
- Recruiting: Trinity Health IHA Medical Group Hematology Oncology - Chelsea Hospital
- Contact: Site Public Contact, 734-712-7251, MCRCwebsitecontactform@stjoeshealth.org
- Principal Investigator: Christopher M. Reynolds
Flint, Michigan, United States, 48503
- Recruiting: Genesee Cancer and Blood Disease Treatment Center
- Contact: Site Public Contact, 810-762-8038, wstrong@ghci.org
- Principal Investigator: Christopher M. Reynolds
Flint, Michigan, United States, 48503
- Recruiting: Genesee Hematology Oncology PC
- Contact: Site Public Contact, 810-762-8038, wstrong@ghci.org
- Principal Investigator: Christopher M. Reynolds
Flint, Michigan, United States, 48503
- Recruiting: Genesys Hurley Cancer Institute
- Contact: Site Public Contact, 810-762-8038, wstrong@ghci.org
- Principal Investigator: Christopher M. Reynolds
Flint, Michigan, United States, 48503
- Recruiting: Hurley Medical Center
- Contact: Site Public Contact, 810-762-8038, wstrong@ghci.org
- Principal Investigator: Christopher M. Reynolds
Lansing, Michigan, United States, 48912
- Recruiting: University of Michigan Health - Sparrow Lansing
- Contact: Site Public Contact, 517-364-3712, harsha.trivedi@umhsparrow.org
- Principal Investigator: Christopher M. Reynolds
Livonia, Michigan, United States, 48154
- Recruiting: Trinity Health Saint Mary Mercy Livonia Hospital
- Contact: Site Public Contact, 734-712-7251, MCRCwebsitecontactform@stjoeshealth.org
- Principal Investigator: Christopher M. Reynolds
Pontiac, Michigan, United States, 48341
- Recruiting: 21st Century Oncology-Pontiac
- Contact: Site Public Contact, 248-858-6215, Emily.Crofts@trinity-health.org
- Principal Investigator: Christopher M. Reynolds
Pontiac, Michigan, United States, 48341
- Recruiting: Saint Joseph Mercy Oakland
- Contact: Site Public Contact, 734-712-7251, MCRCwebsitecontactform@stjoeshealth.org
- Principal Investigator: Christopher M. Reynolds
Ypsilanti, Michigan, United States, 48197
- Recruiting: Trinity Health IHA Medical Group Hematology Oncology Ann Arbor Campus
- Contact: Site Public Contact, 734-712-7251, MCRCwebsitecontactform@stjoeshealth.org
- Principal Investigator: Christopher M. Reynolds
Missouri Locations
Cape Girardeau, Missouri, United States, 63703
- Recruiting: Saint Francis Medical Center
- Contact: Site Public Contact, 573-334-2230, sfmc@sfmc.net
- Principal Investigator: Bryan A. Faller
Osage Beach, Missouri, United States, 65065
- Recruiting: Lake Regional Hospital
- Contact: Site Public Contact, 573-302-2768, clinicaltrials@lakeregional.com
- Principal Investigator: Jay W. Carlson
Montana Locations
Anaconda, Montana, United States, 59711
- Recruiting: Community Hospital of Anaconda
- Contact: Site Public Contact, 406-969-6060, mccinfo@mtcancer.org
- Principal Investigator: John M. Schallenkamp
Bozeman, Montana, United States, 59715
- Recruiting: Bozeman Deaconess Hospital
- Contact: Site Public Contact, 406-969-6060, mccinfo@mtcancer.org
- Principal Investigator: John M. Schallenkamp
Great Falls, Montana, United States, 59405
- Recruiting: Benefis Healthcare- Sletten Cancer Institute
- Contact: Site Public Contact, 406-969-6060, mccinfo@mtcancer.org
- Principal Investigator: John M. Schallenkamp
Missoula, Montana, United States, 59804
- Recruiting: Community Medical Hospital
- Contact: Site Public Contact, 406-969-6060, mccinfo@mtcancer.org
- Principal Investigator: John M. Schallenkamp
New York Locations
Bronx, New York, United States, 10461
- Recruiting: Montefiore Medical Center-Einstein Campus
- Contact: Site Public Contact, 718-379-6866, eskwak@montefiore.org
- Principal Investigator: Balazs Halmos
Bronx, New York, United States, 10467
- Recruiting: Montefiore Medical Center - Moses Campus
- Contact: Site Public Contact, 718-379-6866, eskwak@montefiore.org
- Principal Investigator: Balazs Halmos
Stony Brook, New York, United States, 11794
- Recruiting: Stony Brook University Medical Center
- Contact: Site Public Contact, 800-862-2215
- Principal Investigator: Amna Sher
Ohio Locations
Belpre, Ohio, United States, 45714
- Recruiting: Strecker Cancer Center-Belpre
- Contact: Site Public Contact, 614-488-2745, Jeffh@columbusccop.org
- Principal Investigator: Timothy D. Moore
Canton, Ohio, United States, 44710
- Recruiting: Aultman Health Foundation
- Contact: Site Public Contact, 330-363-7274, ClinicalReserachDept@aultman.com
- Principal Investigator: Raza A. Khan
Centerville, Ohio, United States, 45459
- Recruiting: Miami Valley Hospital South
- Contact: Site Public Contact, 937-528-2900, clinical.trials@daytonncorp.org
- Principal Investigator: Tarek M. Sabagh
Chillicothe, Ohio, United States, 45601
- Recruiting: Adena Regional Medical Center
- Contact: Site Public Contact, 877-779-7585, Jeffh@columbusccop.org
- Principal Investigator: Timothy D. Moore
Cleveland, Ohio, United States, 44109
- Recruiting: MetroHealth Medical Center
- Contact: Site Public Contact, 216-778-7559, ababal@metrohealth.org
- Principal Investigator: Peter Xie
Columbus, Ohio, United States, 43210
- Recruiting: Ohio State University Comprehensive Cancer Center
- Contact: Site Public Contact, 800-293-5066, Jamesline@osumc.edu
- Principal Investigator: Carolyn J. Presley
Columbus, Ohio, United States, 43219
- Recruiting: The Mark H Zangmeister Center
- Contact: Site Public Contact, 614-488-2745, Jeffh@columbusccop.org
- Principal Investigator: Timothy D. Moore
Dayton, Ohio, United States, 45409
- Recruiting: Dayton Blood and Cancer Center
- Contact: Site Public Contact, 937-276-8320
- Principal Investigator: Tarek M. Sabagh
Dayton, Ohio, United States, 45409
- Recruiting: Miami Valley Hospital
- Contact: Site Public Contact, 937-528-2900, clinical.trials@daytonncorp.org
- Principal Investigator: Tarek M. Sabagh
Dayton, Ohio, United States, 45415
- Recruiting: Miami Valley Hospital North
- Contact: Site Public Contact, 937-528-2900, clinical.trials@daytonncorp.org
- Principal Investigator: Tarek M. Sabagh
Oregon Locations
Ontario, Oregon, United States, 97914
- Recruiting: Saint Alphonsus Medical Center-Ontario
- Contact: Site Public Contact, 406-969-6060, mccinfo@mtcancer.org
- Principal Investigator: John M. Schallenkamp
Pennsylvania Locations
Bryn Mawr, Pennsylvania, United States, 19010
- Recruiting: Bryn Mawr Hospital
- Contact: Site Public Contact, 484-476-2649, turzoe@mlhs.org
- Principal Investigator: Deric C. Savior
Media, Pennsylvania, United States, 19063
- Recruiting: Riddle Memorial Hospital
- Contact: Site Public Contact, 484-476-2649, turzoe@mlhs.org
- Principal Investigator: Deric C. Savior
Paoli, Pennsylvania, United States, 19301
- Recruiting: Paoli Memorial Hospital
- Contact: Site Public Contact, 484-476-2649, turzoe@mlhs.org
- Principal Investigator: Deric C. Savior
Philadelphia, Pennsylvania, United States, 19103
- Recruiting: ECOG-ACRIN Cancer Research Group
- Contact: Megan A. Baumgart, megan_baumgart@urmc.rochester.edu
- Principal Investigator: Megan A. Baumgart
West Reading, Pennsylvania, United States, 19611
- Recruiting: Reading Hospital
- Contact: Site Public Contact, 610-988-9323
- Principal Investigator: Terrence P. Cescon
Wynnewood, Pennsylvania, United States, 19096
- Recruiting: Lankenau Medical Center
- Contact: Site Public Contact, 484-476-2649, turzoe@mlhs.org
- Principal Investigator: Deric C. Savior
Virginia Locations
Richmond, Virginia, United States, 23235
- Recruiting: VCU Massey Cancer Center at Stony Point
- Contact: Site Public Contact, ctoclinops@vcu.edu
- Principal Investigator: Jonathan D. Berkman
Richmond, Virginia, United States, 23298
- Recruiting: Virginia Commonwealth University/Massey Cancer Center
- Contact: Site Public Contact, CTOclinops@vcu.edu
- Principal Investigator: Jonathan D. Berkman
Wisconsin Locations
Antigo, Wisconsin, United States, 54409
- Recruiting: Langlade Hospital and Cancer Center
- Contact: Site Public Contact, 715-623-9869, Juli.Alford@aspirus.org
- Principal Investigator: Andrew J. Huang
Appleton, Wisconsin, United States, 54911
- Recruiting: ThedaCare Regional Cancer Center
- Contact: Site Public Contact, 920-364-3604, ResearchDept@thedacare.org
- Principal Investigator: Matthias Weiss
Berlin, Wisconsin, United States, 54923
- Recruiting: ThedaCare Cancer Care - Berlin
- Contact: Site Public Contact, 920-364-3605, ResearchDept@thedacare.org
- Principal Investigator: Matthias Weiss
La Crosse, Wisconsin, United States, 54601
- Recruiting: Gundersen Lutheran Medical Center
- Contact: Site Public Contact, 608-775-2385, cancerctr@gundersenhealth.org
- Principal Investigator: Kurt Oettel
Medford, Wisconsin, United States, 54451
- Recruiting: Aspirus Medford Hospital
- Contact: Site Public Contact, 715-847-2353, Beth.Knetter@aspirus.org
- Principal Investigator: Andrew J. Huang
Mukwonago, Wisconsin, United States, 53149
- Recruiting: ProHealth D N Greenwald Center
- Contact: Site Public Contact, research.institute@phci.org
- Principal Investigator: Timothy R. Wassenaar
Neenah, Wisconsin, United States, 54956
- Recruiting: ThedaCare Regional Medical Center - Neenah
- Contact: Site Public Contact, 920-364-3605, ResearchDept@thedacare.org
- Principal Investigator: Matthias Weiss
New London, Wisconsin, United States, 54961
- Recruiting: ThedaCare Cancer Care - New London
- Contact: Site Public Contact, 920-364-3605, ResearchDept@thedacare.org
- Principal Investigator: Matthias Weiss
Oconomowoc, Wisconsin, United States, 53066
- Recruiting: ProHealth Oconomowoc Memorial Hospital
- Contact: Site Public Contact, 262-928-7878
- Principal Investigator: Timothy R. Wassenaar
Oshkosh, Wisconsin, United States, 54904
- Recruiting: ThedaCare Cancer Care - Oshkosh
- Contact: Site Public Contact, 920-364-3605, ResearchDept@thedacare.org
- Principal Investigator: Matthias Weiss
Rhinelander, Wisconsin, United States, 54501
- Recruiting: Ascension Saint Mary's Hospital
- Contact: Site Public Contact, 715-847-2353, Beth.Knetter@aspirus.org
- Principal Investigator: Andrew J. Huang
Shawano, Wisconsin, United States, 54166
- Recruiting: ThedaCare Cancer Care - Shawano
- Contact: Site Public Contact, 920-364-3605, ResearchDept@thedacare.org
- Principal Investigator: Matthias Weiss
Stevens Point, Wisconsin, United States, 54481
- Recruiting: Ascension Saint Michael's Hospital
- Contact: Site Public Contact, 715-847-2353, Beth.Knetter@aspirus.org
- Principal Investigator: Andrew J. Huang
Waukesha, Wisconsin, United States, 53188
- Recruiting: ProHealth Waukesha Memorial Hospital
- Contact: Site Public Contact, 262-928-7632
- Principal Investigator: Timothy R. Wassenaar
Waukesha, Wisconsin, United States, 53188
- Recruiting: UW Cancer Center at ProHealth Care
- Contact: Site Public Contact, 262-928-5539, Chanda.miller@phci.org
- Principal Investigator: Timothy R. Wassenaar
Waupaca, Wisconsin, United States, 54981
- Recruiting: ThedaCare Cancer Care - Waupaca
- Contact: Site Public Contact, 920-364-3605, ResearchDept@thedacare.org
- Principal Investigator: Matthias Weiss
Wausau, Wisconsin, United States, 54401
- Recruiting: Aspirus Regional Cancer Center
- Contact: Site Public Contact, 877-405-6866
- Principal Investigator: Andrew J. Huang
Wisconsin Rapids, Wisconsin, United States, 54494
- Recruiting: Aspirus Cancer Care - Wisconsin Rapids
- Contact: Site Public Contact, 715-422-7718
- Principal Investigator: Andrew J. Huang
This clinical trial is sponsored by the National Cancer Institute (NCI)
Link to clinicaltrails.gov