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Comparing Standard Therapy to Treat Hodgkin Lymphoma to the Use of Two Drugs, Brentuximab Vedotin and Nivolumab, in 5-60 year old patients

This study is looking at the benefits of adding immunotherapy to the usual treatment for early-stage classical Hodgkin lymphoma (stages I and II). The usual treatment includes chemotherapy, and sometimes radiation. Adding immunotherapy to standard treatment might improve survival chances and could result in fewer side effects, both short and long term, for people with this type of lymphoma.

This study aims to find out if this combined approach is more effective than the standard treatment alone.

NCI-2022-10845

  • Immunotherapy: The added treatments are two types of immunotherapy: brentuximab vedotin and nivolumab. Brentuximab vedotin combines an antibody that targets cancer cells with a drug that kills them. Nivolumab helps your immune system fight the cancer more effectively. Both of these medicines are already available for use in patients with cancer.
  • Chemotherapy: The standard chemotherapy drugs used in this trial include doxorubicin hydrochloride, bleomycin sulfate, vinblastine sulfate, dacarbazine, procarbazine hydrochloride, cyclophosphamide, etoposide, vincristine, and prednisone. These drugs work in different ways to stop cancer cells from growing and dividing, which helps kill them or stop them from spreading.
  • Radiation Therapy: For some patients, high-energy x-rays may be used to kill tumor cells and shrink tumors.
  • Brentuximab is part of a unique class of therapy known as antibody drug conjugates designed to target cells expressing CD30.
    • CD30 is a member of the tumor necrosis factor receptor family and is expressed on the surface of certain peripheral T-cell lymphomas (PTCL), such as systemic anaplastic large cell lymphoma (sALCL) cells, and on Hodgkin Reed-Sternberg (HRS) cells in classical Hodgkin lymphoma (cHL)
    • Detection of CD30 can help identify patients who may be appropriate candidates for CD30-directed therapy

    Nivolumab is a type of medication known as an immune checkpoint inhibitor. It works by targeting a protein on immune cells called PD-1 (programmed death-1). Normally, PD-1 acts as a type of "off switch" that helps keep the body’s immune responses in check by preventing the activation of T-cells, which could otherwise attack normal cells in the body.

    • Cancer cells can take advantage of this pathway by expressing PD-L1, a ligand for PD-1, thereby protecting themselves from being attacked by the immune system. Nivolumab blocks PD-1, disrupting this pathway and enabling the immune system, specifically T-cells, to attack cancer cells more effectively.
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  • Rapid Early Responders to standard chemotherapy: Add on immunotherapy

    • Objective: Assess if immunotherapy (brentuximab vedotin and nivolumab) is more effective (than continuing standard chemotherapy for patients who show a quick, positive response to initial treatment.‍
    • Approach: After the first two cycles of standard chemotherapy (ABVD - doxorubicin, bleomycin, vinblastine, dacarbazine), patients who quickly show improvement on their PET scans will switch to immunotherapy to see if this enhances their progression-free survival (PFS), meaning the cancer does not worsen.

    Slow Early Responders to standard chemotherapy: Add on immunotherapy + radiotherapy

    • Objective: Evaluate if adding immunotherapy and involved site radiation therapy (ISRT) to the treatment regimen provides better outcomes (progressional free survival or PFS) than standard chemotherapy alone for patients who show a slower initial response.
    • Approach: Patients showing a slower response on early PET scans after two cycles of ABVD will either continue with standard chemotherapy or receive a combination of immunotherapy and radiation. The goal is to compare the effectiveness in preventing cancer progression.

    These strategies aim to customize treatment based on how quickly patients respond to initial chemotherapy, optimizing the chance for better long-term outcomes.

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Age Range:

  • Participants must be between 5 and 60 years old at the time of enrollment.

Disease Confirmation and Stage:

  • You must be newly diagnosed with early stage (I or II) classic Hodgkin lymphoma. This includes various subtypes like nodular sclerosis or mixed cellularity.
  • There needs to be at least one measurable area of the disease, with a lesion size of 1.5 cm in diameter or larger.

Diagnostic Tests:

  • A PET scan (using CT or MRI) must have been completed within 42 days before joining the study. If a PET-MRI is used, an additional CT scan with contrast is required.
  • Chest X-rays are needed for assessment. Children (5-17 years) require an upright chest X-ray. Adults can have either a chest X-ray or a CT scan of the chest.

Health and Performance Status:

  • Adults (18 years and older) must have a Zubrod performance score of 0, 1, or 2, indicating how the disease affects their daily living abilities.
  • Children (under 18 years) should have a Lansky performance score of 50 or above, showing a moderate level of activity.

Kidney Function:

  • Specific creatinine levels are required depending on age and gender to ensure good kidney function.
  • Adults need a creatinine clearance of at least 30 mL/min, which shows how well the kidneys filter waste.
  • Tests for GFR (a measure of kidney function) using certain methods are necessary, not just estimates.

Liver and Heart Function:

  • Total bilirubin levels must be no more than twice the normal limit unless it’s due to specific conditions.
  • Liver enzymes (AST and ALT) should be within three times the normal range unless there are extenuating circumstances.
  • Heart function should be confirmed as adequate through various scans, ensuring at least a 27% shortening fraction or 50% ejection fraction.

Lung Function:

  • Lung capacity should be at least 50% of the expected value for someone your age and health condition, checked by a lung function test or, if that’s not possible, an oxygen saturation of more than 92% on room air.

Other Conditions:

  • Patients with HIV must be on effective therapy with an undetectable viral load.
  • Those with hepatitis B or C must have controlled or resolved infections.

This study aims to ensure participants are in a condition that allows them to safely receive and potentially benefit from the treatment while providing accurate data on the effectiveness of the therapies being tested.

  • Specific Hodgkin Lymphoma Type: If you have nodular lymphocyte predominant Hodgkin lymphoma, you are not eligible.
  • Lung Issues: Anyone with active lung diseases like interstitial pneumonitis or lung disease.
  • Immune System Conditions: Those with inherited or acquired immune deficiencies that aren’t well-controlled, or if you're taking medication for these conditions.
  • Serious Health Issues: If you have uncontrolled illnesses that could affect safety, such as certain infections, heart conditions, or severe digestive problems.
  • Recent Use of Immunosuppressants: You shouldn't have taken high doses of steroids or other immune-weakening medicines within 14 days before joining. Low doses for hormone replacement or topical steroids are okay unless you have active autoimmune disease.
  • Neurological Conditions: If you have significant nerve damage or Charcot-Marie-Tooth syndrome.
  • Other Cancers or Treatments: If you have another type of cancer or have had treatments like chemotherapy, radiation, or antibody treatments for Hodgkin lymphoma, or any organ or stem cell transplant.
  • Vaccinations: You shouldn't have received live vaccines within 30 days before starting the study. mRNA vaccines like COVID-19 vaccines are allowed.

Requirements for Women and Family Planning:

  • Pregnancy: Women must not be pregnant and must have a pregnancy test done before joining because the study drugs could harm the fetus.
  • Breastfeeding: If you are breastfeeding or plan to start, you are not eligible.
  • Contraception: If you are sexually active and can have children, you must agree to use effective birth control during and for several months after the treatment to avoid pregnancy.

Consent and Regulations:

  • Informed Consent: You and/or your guardians must understand and sign an informed consent form.
  • Regulatory Compliance: All study activities must comply with local and national health regulations.
Alabama Locations

Mobile, Alabama, United States, 36604

  • Recruiting: USA Health Strada Patient Care Center
  • Contact: Site Public Contact, 800-388-8721
  • Principal Investigator: Hamayun Imran
Alaska Locations

Anchorage, Alaska, United States, 99508

Arizona Locations

Goodyear, Arizona, United States, 85338

  • Recruiting: CTCA at Western Regional Medical Center
  • Contact: Site Public Contact, 623-207-3000
  • Principal Investigator: Jeffrey R. Schriber
Arkansas Locations

Little Rock, Arkansas, United States, 72202-3591

  • Recruiting: Arkansas Children's Hospital
  • Contact: Site Public Contact, 501-364-7373
  • Principal Investigator: David L. Becton
California Locations

Downey, California, United States, 90242

  • Recruiting: Kaiser Permanente Downey Medical Center
  • Contact: Site Public Contact, 626-564-3455
  • Principal Investigator: Robert M. Cooper

Duarte, California, United States, 91010

  • Recruiting: City of Hope Comprehensive Cancer Center
  • Contact: Site Public Contact, 800-826-4673, becomingapatient@coh.org
  • Principal Investigator: Alex F. Herrera

Irvine, California, United States, 92618

  • Recruiting: City of Hope at Irvine Lennar
  • Contact: Site Public Contact, 877-467-3411
  • Principal Investigator: Alex F. Herrera

Loma Linda, California, United States, 92354

  • Recruiting: Loma Linda University Medical Center
  • Contact: Site Public Contact, 909-558-4050
  • Principal Investigator: Albert Kheradpour

Long Beach, California, United States, 90806

  • Recruiting: Miller Children's and Women's Hospital Long Beach
  • Contact: Site Public Contact, 562-933-5600
  • Principal Investigator: Jacqueline N. Casillas

Los Angeles, California, United States, 90027

  • Recruiting: Children's Hospital Los Angeles
  • Contact: Site Public Contact, 323-361-4110
  • Principal Investigator: Andrew Doan

Los Angeles, California, United States, 90048

  • Recruiting: Cedars Sinai Medical Center
  • Contact: Site Public Contact, 310-423-8965
  • Principal Investigator: Nicole M. Baca

Oakland, California, United States, 94611

  • Recruiting: Kaiser Permanente-Oakland
  • Contact: Site Public Contact, 877-642-4691, Kpoct@kp.org
  • Principal Investigator: Aarati V. Rao

Orange, California, United States, 92868

  • Recruiting: Children's Hospital of Orange County
  • Contact: Site Public Contact, 714-509-8646, oncresearch@choc.org
  • Principal Investigator: Elyssa M. Rubin

San Diego, California, United States, 92123

  • Recruiting: Rady Children's Hospital - San Diego
  • Contact: Site Public Contact, 858-966-5934
  • Principal Investigator: William D. Roberts

South Pasadena, California, United States, 91030

  • Recruiting: City of Hope South Pasadena
  • Contact: Site Public Contact, 800-826-4673, becomingapatient@coh.org
  • Principal Investigator: Alex F. Herrera

Upland, California, United States, 91786

  • Recruiting: City of Hope Upland
  • Contact: Site Public Contact, 800-826-4673, becomingapatient@coh.org
  • Principal Investigator: Alex F. Herrera

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Alabama Locations

  • Birmingham, AL 35233
    • University of Alabama at Birmingham Cancer Center
    • Contact: Site Public Contact, 205-934-0220, tmyrick@uab.edu
    • Principal Investigator: Michael D. Toboni

Arizona Locations

  • Tucson, AZ 85719
    • Banner University Medical Center - Tucson
    • Contact: Site Public Contact, UACC-IIT@uacc.arizona.edu
    • Principal Investigator: Setsuko K. Chambers
    • University of Arizona Cancer Center-North Campus
    • Contact: Site Public Contact, UACC-IIT@uacc.arizona.edu
    • Principal Investigator: Setsuko K. Chambers

Arkansas Locations

  • Little Rock, AR 72205
    • University of Arkansas for Medical Sciences
    • Contact: Site Public Contact, 501-686-8274
    • Principal Investigator: Heather R. Williams

California Locations

  • Auburn, CA 95602
  • Berkeley, CA 94704
  • Concord, CA 94520
    • John Muir Medical Center-Concord Campus
    • Contact: Site Public Contact, 925-674-2580
    • Principal Investigator: Babak Edraki
  • Duarte, CA 91010
    • City of Hope Comprehensive Cancer Center
    • Contact: Site Public Contact, 800-826-4673, becomingapatient@coh.org
    • Principal Investigator: Joshua G. Cohen
  • Huntington Beach, CA 92648
    • City of Hope at Huntington Beach
    • Contact: Site Public Contact, 877-467-3411
    • Principal Investigator: Joshua G. Cohen

Irvine, CA 92618

  • City of Hope at Irvine Lennar
    • Contact: Site Public Contact, 877-467-3411
    • Principal Investigator: Joshua G. Cohen
  • Kaiser Permanente-Irvine

Long Beach, CA 90813

  • City of Hope at Long Beach Elm
    • Contact: Site Public Contact, 877-467-3411
    • Principal Investigator: Joshua G. Cohen

Los Angeles, CA 90027

  • Kaiser Permanente Los Angeles Medical Center

Modesto, CA 95355

Mountain View, CA 94040

Riverside, CA 92505

  • Kaiser Permanente-Riverside

Roseville, CA 95661

Sacramento, CA 95817

  • University of California Davis Comprehensive Cancer Center
    • Contact: Site Public Contact, 916-734-3089
    • Principal Investigator: Rebecca A. Brooks

San Francisco, CA 94115

Sunnyvale, CA 94086

Upland, CA 91786

  • City of Hope Upland

Walnut Creek, CA 94598

  • John Muir Medical Center-Walnut Creek
    • Contact: Site Public Contact, 925-941-4246
    • Principal Investigator: Babak Edraki

Colorado Locations

  • Aurora, CO 80045
    • UCHealth University of Colorado Hospital
    • Contact: Site Public Contact, 720-848-0650
    • Principal Investigator: Marisa R. Moroney

Denver, CO 80206

  • UCHealth - Cherry Creek
    • Contact: Site Public Contact, 412-339-5294, Roster@nrgoncology.org
    • Principal Investigator: Marisa R. Moroney

Greeley, CO 80631

Highlands Ranch, CO 80129

  • UCHealth Highlands Ranch Hospital
    • Contact: Site Public Contact, 720-848-0650
    • Principal Investigator: Marisa R. Moroney

Loveland, CO 80539

Connecticut Locations

  • Danbury, CT 06810
    • Danbury Hospital
    • Contact: Site Public Contact, 203-739-8074
    • Principal Investigator: Wenli Gao
  • Derby, CT 06418
    • Smilow Cancer Hospital-Derby Care Center
    • Contact: Site Public Contact, 203-785-5702, canceranswers@yale.edu
    • Principal Investigator: Alessandro D. Santin
  • Fairfield, CT 06824
    • Smilow Cancer Hospital Care Center-Fairfield
    • Contact: Site Public Contact, 203-785-5702, canceranswers@yale.edu
    • Principal Investigator: Alessandro D. Santin
  • Glastonbury, CT 06033
    • Smilow Cancer Hospital Care Center at Glastonbury
    • Contact: Site Public Contact, 203-785-5702, canceranswers@yale.edu
    • Principal Investigator: Alessandro D. Santin
  • Greenwich, CT 06830
    • Smilow Cancer Hospital Care Center at Greenwich
    • Contact: Site Public Contact, 203-785-5702, canceranswers@yale.edu
    • Principal Investigator: Alessandro D. Santin
  • Guilford, CT 06437
    • Smilow Cancer Hospital Care Center - Guilford
    • Contact: Site Public Contact, 203-785-5702, canceranswers@yale.edu
    • Principal Investigator: Alessandro D. Santin
  • Hartford, CT 06105
    • Smilow Cancer Hospital Care Center at Saint Francis
    • Contact: Site Public Contact, 203-785-5702, canceranswers@yale.edu
    • Principal Investigator: Alessandro D. Santin
  • New Haven, CT 06520
    • Yale University
    • Contact: Site Public Contact, 203-785-5702, canceranswers@yale.edu
    • Principal Investigator: Alessandro D. Santin
  • North Haven, CT 06473
    • Yale-New Haven Hospital North Haven Medical Center
    • Contact: Site Public Contact, 203-785-5702, canceranswers@yale.edu
    • Principal Investigator: Alessandro D. Santin
  • Norwalk, CT 06856
  • Stamford, CT 06902
    • Smilow Cancer Hospital Care Center at Long Ridge
    • Contact: Site Public Contact, 203-785-5702, canceranswers@yale.edu
    • Principal Investigator: Alessandro D. Santin
  • Torrington, CT 06790
    • Smilow Cancer Hospital-Torrington Care Center
    • Contact: Site Public Contact, 203-785-5702, canceranswers@yale.edu
    • Principal Investigator: Alessandro D. Santin
  • Trumbull, CT 06611
    • Smilow Cancer Hospital Care Center-Trumbull
    • Contact: Site Public Contact, 203-785-5702, canceranswers@yale.edu
    • Principal Investigator: Alessandro D. Santin
  • Waterbury, CT 06708
    • Smilow Cancer Hospital-Waterbury Care Center
    • Contact: Site Public Contact, 203-785-5702, canceranswers@yale.edu
    • Principal Investigator: Alessandro D. Santin
  • Waterford, CT 06385
    • Smilow Cancer Hospital Care Center - Waterford
    • Contact: Site Public Contact, 203-785-5702, canceranswers@yale.edu
    • Principal Investigator: Alessandro D. Santin

Delaware Locations

  • Newark, DE 19713
    • Helen F Graham Cancer Center
    • Contact: Site Public Contact, 302-623-4450, lbarone@christianacare.org
    • Principal Investigator: Gregory A. Masters
    • Medical Oncology Hematology Consultants PA
    • Contact: Same as above
    • Principal Investigator: Same as above

District of Columbia Locations

  • Washington, DC 20016
    • Sibley Memorial Hospital
    • Contact: Site Public Contact, 202-243-2373, jquiver1@jhmi.edu
    • Principal Investigator: Amanda N. Fader
  • Washington, DC 20037
    • George Washington University Medical Center
    • Contact: Site Public Contact, 202-741-2981
    • Principal Investigator: Nicole P. Chappell

Florida Locations

  • Orlando, FL 32803
  • Sarasota, FL 34236
    • Florida Cancer Specialists - Sarasota Downtown
    • Contact: Site Public Contact, 941-957-1000
    • Principal Investigator: Beverly Long
  • Sarasota, FL 34239
    • First Physicians Group-Sarasota
    • Contact: Site Public Contact, 941-917-8383
    • Principal Investigator: Beverly Long
    • Sarasota Memorial Hospital
    • Contact: Site Public Contact, 941-917-2225
    • Principal Investigator: Beverly Long
  • Venice, FL 34292
    • Florida Cancer Specialists - Venice Healthpark
    • Contact: Site Public Contact, 412-339-5294, Roster@nrgoncology.org
    • Principal Investigator: Beverly Long

Georgia Locations

  • Atlanta, GA 30303
    • Grady Health System
    • Contact: Site Public Contact, 404-489-9164
    • Principal Investigator: Namita Khanna
  • Atlanta, GA 30308
    • Emory University Hospital Midtown
    • Contact: Site Public Contact, 888-946-7447
    • Principal Investigator: Namita Khanna
  • Atlanta, GA 30322
    • Emory University Hospital/Winship Cancer Institute
    • Contact: Site Public Contact, 404-778-1868
    • Principal Investigator: Namita Khanna
  • Atlanta, GA 30342
    • Emory Saint Joseph's Hospital
    • Contact: Site Public Contact, 404-851-7115
    • Principal Investigator: Namita Khanna
  • Augusta, GA 30912
    • Augusta University Medical Center
    • Contact: Site Public Contact, 706-721-2388, ga_cares@augusta.edu
    • Principal Investigator: Sharad A. Ghamande
  • Savannah, GA 31405
    • Lewis Cancer and Research Pavilion at Saint Joseph's/Candler
    • Contact: Site Public Contact, 912-819-5704, underberga@sjchs.org
    • Principal Investigator: Sarah E. Gill

Hawaii Locations

  • Honolulu, HI 96813
    • Queen's Medical Center
    • Contact: Site Public Contact, 808-545-8548
    • Principal Investigator: Michael E. Carney
  • Honolulu, HI 96826
    • Kapiolani Medical Center for Women and Children
    • Contact: Site Public Contact, 808-983-6090
    • Principal Investigator: Michael E. Carney

Idaho Locations

  • Boise, ID 83706
    • Saint Alphonsus Cancer Care Center-Boise
    • Contact: Site Public Contact, 734-712-3671, stephanie.couch@stjoeshealth.org
    • Principal Investigator: John M. Schallenkamp
  • Boise, ID 83712
    • Saint Luke's Cancer Institute - Boise
    • Contact: Site Public Contact, 208-381-2774, eslinget@slhs.org
    • Principal Investigator: Nitya Alluri
  • Caldwell, ID 83605
    • Saint Alphonsus Cancer Care Center-Caldwell
    • Contact: Site Public Contact, 734-712-3671, stephanie.couch@stjoeshealth.org
    • Principal Investigator: John M. Schallenkamp
  • Coeur d'Alene, ID 83814
    • Kootenai Health - Coeur d'Alene
    • Contact: Site Public Contact, 406-969-6060, mccinfo@mtcancer.org
    • Principal Investigator: John M. Schallenkamp

Fruitland, ID 83619

  • Saint Luke's Cancer Institute - Fruitland
  • Contact: Site Public Contact, 208-381-2774, eslinget@slhs.org
  • Principal Investigator: Nitya Alluri

Meridian, ID 83642

  • Saint Luke's Cancer Institute - Meridian
  • Contact: Site Public Contact, 208-381-2774, eslinget@slhs.org
  • Principal Investigator: Nitya Alluri

Nampa, ID 83686

  • Saint Luke's Cancer Institute - Nampa
  • Contact: Site Public Contact, 208-381-2774, eslinget@slhs.org
  • Principal Investigator: Nitya Alluri

Nampa, ID 83687

  • Saint Alphonsus Cancer Care Center-Nampa
  • Contact: Site Public Contact, 406-969-6060, mccinfo@mtcancer.org
  • Principal Investigator: John M. Schallenkamp

Post Falls, ID 83854

  • Kootenai Clinic Cancer Services - Post Falls
  • Contact: Site Public Contact, 406-969-6060, mccinfo@mtcancer.org
  • Principal Investigator: John M. Schallenkamp

Sandpoint, ID 83864

  • Kootenai Cancer Clinic
  • Contact: Site Public Contact, 406-969-6060, mccinfo@mtcancer.org
  • Principal Investigator: John M. Schallenkamp

Twin Falls, ID 83301

  • Saint Luke's Cancer Institute - Twin Falls
  • Contact: Site Public Contact, 208-381-2774, eslinget@slhs.org
  • Principal Investigator: Nitya Alluri

Illinois Locations

  • Arlington Heights, IL 60005
    • Northwest Community Hospital
    • Contact: Site Public Contact, 847-618-4968
    • Principal Investigator: Kathryn A. Mills
  • Aurora, IL 60504
  • Centralia, IL 62801
    • Centralia Oncology Clinic
    • Contact: Site Public Contact, 217-876-4762, morganthaler.jodi@mhsil.com
    • Principal Investigator: Bryan A. Faller
  • Chicago, IL 60611
    • Northwestern University
    • Contact: Site Public Contact, 312-695-1301, cancer@northwestern.edu
    • Principal Investigator: Emily Hinchcliff

Chicago, IL 60612

  • John H Stroger Jr Hospital of Cook County
  • Contact: Site Public Contact, 312-864-5204
  • Principal Investigator: Thomas E. Lad
  • Rush University Medical Center
  • Contact: Site Public Contact, 312-942-5498, clinical_trials@rush.edu
  • Principal Investigator: Summer B. Dewdney

Chicago, IL 60637

Danville, IL 61832

  • Carle at The Riverfront
  • Contact: Site Public Contact, 800-446-5532, Research@Carle.com
  • Principal Investigator: Pratima Chalasani

Decatur, IL 62526

  • Cancer Care Specialists of Illinois - Decatur
  • Contact: Site Public Contact, 217-876-4762, morganthaler.jodi@mhsil.com
  • Principal Investigator: Bryan A. Faller
  • Decatur Memorial Hospital
  • Contact: Site Public Contact, 217-876-4762, morganthaler.jodi@mhsil.com
  • Principal Investigator: Bryan A. Faller

DeKalb, IL 60115

  • Northwestern Medicine Cancer Center Kishwaukee
  • Contact: Site Public Contact, 630-352-5360, Donald.Smith3@nm.org
  • Principal Investigator: Emily Hinchcliff

Effingham, IL 62401

  • Carle Physician Group-Effingham
  • Contact: Site Public Contact, 800-446-5532, Research@carle.com
  • Principal Investigator: Pratima Chalasani
  • Crossroads Cancer Center
  • Contact: Site Public Contact, 217-876-4762, morganthaler.jodi@mhsil.com
  • Principal Investigator: Bryan A. Faller

Evanston, IL 60201

  • NorthShore University HealthSystem-Evanston Hospital
  • Contact: Site Public Contact, 847-570-2109
  • Principal Investigator: Mary T. Jenkins Vogel

Geneva, IL 60134

  • Northwestern Medicine Cancer Center Delnor
  • Contact: Site Public Contact, 630-352-5360, Donald.Smith3@nm.org
  • Principal Investigator: Emily Hinchcliff

Glenview, IL 60026

  • NorthShore University HealthSystem-Glenbrook Hospital
  • Contact: Site Public Contact, 847-570-2109
  • Principal Investigator: Mary T. Jenkins Vogel

Highland Park, IL 60035

  • NorthShore University HealthSystem-Highland Park Hospital
  • Contact: Site Public Contact, 847-570-2109
  • Principal Investigator: Mary T. Jenkins Vogel

Hinsdale, IL 60521

  • Sudarshan K Sharma MD Limited-Gynecologic Oncology
  • Contact: Site Public Contact, 630-856-6757
  • Principal Investigator: Sudarshan K. Sharma

Lake Forest, IL 60045

Mattoon, IL 61938

  • Carle Physician Group-Mattoon/Charleston
  • Contact: Site Public Contact, 800-446-5532, Research@carle.com
  • Principal Investigator: Pratima Chalasani

New Lenox, IL 60451

O'Fallon, IL 62269

  • Cancer Care Center of O'Fallon
  • Contact: Site Public Contact, 217-876-4762, morganthaler.jodi@mhsil.com
  • Principal Investigator: Bryan A. Faller

Orland Park, IL 60462

Springfield, IL 62702

  • Southern Illinois University School of Medicine
  • Contact: Site Public Contact, 217-545-7929
  • Principal Investigator: Bryan A. Faller
  • Springfield Clinic
  • Contact: Site Public Contact, 800-444-7541
  • Principal Investigator: Bryan A. Faller
  • Memorial Medical Center
  • Contact: Site Public Contact, 217-528-7541, pallante.beth@mhsil.com
  • Principal Investigator: Bryan A. Faller

Urbana, IL 61801

  • Carle Cancer Center
  • Contact: Site Public Contact, 800-446-5532, Research@carle.com
  • Principal Investigator: Pratima Chalasani

Warrenville, IL 60555

  • Northwestern Medicine Cancer Center Warrenville
  • Contact: Site Public Contact, 630-352-5360, Donald.Smith3@nm.org
  • Principal Investigator: Emily Hinchcliff

Yorkville, IL 60560

Indiana Locations

Crown Point, IN 46307

  • Northwest Cancer Center - Main Campus
  • Contact: Site Public Contact, 219-310-2550
  • Principal Investigator: Pratima Chalasani

Dyer, IN 46311

  • Northwest Oncology LLC
  • Contact: Site Public Contact, 219-924-8178
  • Principal Investigator: Pratima Chalasani

Goshen, IN 46526

  • Goshen Center for Cancer Care
  • Contact: Site Public Contact, 574-364-2973, cccois@goshenhealth.com
  • Principal Investigator: Pamela J. Stone

Hobart, IN 46342

  • Northwest Cancer Center - Hobart
  • Contact: Site Public Contact, 219-947-1795
  • Principal Investigator: Pratima Chalasani
    • Saint Mary Medical Center
    • Contact: Site Public Contact, 219-836-6875, CancerResearch@COMHS.org
    • Principal Investigator: Pratima Chalasani

Indianapolis, IN 46202

  • Indiana University/Melvin and Bren Simon Cancer Center
  • Contact: Site Public Contact, 317-278-5632, iutrials@iu.edu
  • Principal Investigator: Jessica E. Parker

Indianapolis, IN 46237

  • Franciscan Health Indianapolis
  • Contact: Site Public Contact, 317-528-7060
  • Principal Investigator: Harsha Ranganath

Indianapolis, IN 46260

  • Ascension Saint Vincent Indianapolis Hospital
  • Contact: Site Public Contact, 317-338-2194, research@stvincent.org
  • Principal Investigator: Megan E. Buechel

Indianapolis, IN 46312

  • Saint Catherine Hospital
  • Contact: Site Public Contact, 412-339-5294, Roster@nrgoncology.org
  • Principal Investigator: Pratima Chalasani

Lafayette, IN 47905

  • Franciscan Saint Elizabeth Health - Lafayette East
  • Contact: Site Public Contact, 888-823-5923, ctsucontact@westat.com
  • Principal Investigator: Harsha Ranganath

Mooresville, IN 46158

  • Franciscan Health Mooresville
  • Contact: Site Public Contact, 317-834-3603
  • Principal Investigator: Harsha Ranganath

Munster, IN 46321

  • The Community Hospital
  • Contact: Site Public Contact, 219-836-3349
  • Principal Investigator: Pratima Chalasani
    • Women's Diagnostic Center - Munster
    • Contact: Site Public Contact, 219-934-8869, mnicholson@comhs.org
    • Principal Investigator: Pratima Chalasani

South Bend, IN 46601

  • Memorial Hospital of South Bend
  • Contact: Site Public Contact, 800-284-7370
  • Principal Investigator: Nonyem A. Onujiogu

Valparaiso, IN 46383

  • Northwest Cancer Center - Valparaiso
  • Contact: Site Public Contact, 219-836-6875, CancerResearch@COMHS.org
  • Principal Investigator: Pratima Chalasani

‍

Any other information

Link to clinicaltrails.gov

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*The information provided here is not intended to be medical advice. Please use your discretion and your health care team’s advice for your healthcare decisions.

At Together4Cancer, our mission is to empower patients and caregivers with clear, accessible information and practical guidance for navigating the cancer journey.

Drawing from my 15 years of experience as an oncology pharmacist and caregiver, I understand firsthand the overwhelming challenges cancer brings, even with resources and knowledge.

This platform is designed to share vital knowledge, provide crucial resources, and promote self-advocacy, ensuring people ask the right questions and make informed healthcare decisions. We’re here to make the path through cancer easier, one step at a time.

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